FP268MOLECULAR SIMILARITY OF RENAL AGEING AND CKD REVEALED BY URINARY PROTEOMICS

Urinary proteomics in diabetes and CKD.

Urinary biomarkers for diabetes, diabetic nephropathy, and nondiabetic proteinuric renal diseases were sought. For 305 individuals, biomarkers were defined and validated in blinded data sets using high-resolution capillary electrophoresis coupled with electrospray-ionization mass spectrometry. A panel of 40 biomarkers distinguished patients with diabetes from healthy individuals with 89% sensit...

Renal Transplantation and Urinary Proteomics

The use of urinary proteomics in the assessment of suitability of mouse models for ageing

Ageing is a complex process characterised by a systemic and progressive deterioration of biological functions. As ageing is associated with an increased prevalence of age-related chronic disorders, understanding its underlying molecular mechanisms can pave the way for therapeutic interventions and managing complications. Animal models such as mice are commonly used in ageing research as they ha...

Urinary creatinine and survival in CKD.

Low muscle mass is associated with risk of CKD progression, cardiovascular disease events, and mortality in avarietyof settings (1). It iswidelyhypothesized that these associations may be confounded by conditions associated with low muscle mass, including frailty, poor physical fitness, poor nutritional status, and greater comorbidity. However, lowmuscle is also hypothesized to worsen insulin r...

Renal Autotransplantation for Urinary Undiversion

Urinary dh ersion has been performed in the past in many patients for different indications. In many of these patients urine can be undiverted to its natural path (urinary undiversion) using new techniques. The most common type of urinary dhersions are: Ileal condiut, ureterosigmoidostomy, cutaneous ureterostomy and nephrostomy. There have been many different methods reported for urinary undive...